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  1. P. Chen, W. Yang, K. Nagaoka, G. L. Huang, T. Miyazaki, T. Hong, S. Li, K. Igarashi, K. Takeda, K. Kakimi, K. Kataoka, H. Cabral, An IL-12-based nanocytokine safely potentiates anticancer immunity through spatiotemporal control of inflammation to eradicate advanced cold tumors. Adv. Sci. in press. (DOI: 10.1002/advs.202205139)
  2. W. Yang, T. Miyazaki, Y. Nakagawa, E. Boonstra, K. Masuda, Y. Nakashima, P. Chen, L. Mixich, K. Barthelmes, A. Matsumoto, P. Mi, S. Uchida, H. Cabral, Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via ƒÎ-ƒÎ stacking-assisted micellar assembly. Sci. Technol. Adv. Mater. in press. (DOI: 10.1080/14686996.2023.2170164)
  3. S. Tanabe, S. Quader, R. Ono, H. Cabral, K. Aoyagi, A. Hirose, E. J. Perkins, H. Yokozaki, H. Sasaki, Regulation of epithelial-mesenchymal transition pathway and artificial intelligence-based modeling for pathway activity prediction. Onco 3(1) 13-25 (2023) (DOI: 10.3390/onco3010002)
  4. M. Panagi, F. Mpekris, P. Chen, C. Voutouri, Y. Nakagawa, J. D. Martin, T. Hiroi, H. Hashimoto, P. Demetriou, C. Pierides, R. Samuel, A. Stylianou, C. Michael, S. Fukushima, P. Georgiou, P. Papageorgis, P. Ch. Papaphilippou, L. Koumas, P. Costeas, G. Ishii, M. Kojima, K. Kataoka, H. Cabral, T. Stylianopoulos, Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models. Nat. Commun. 13(7165) Online Only (2022) (DOI: 10.1038/s41467-022-34744-1)
  5. P. Chen, W. Yang, T. Hong, T. Miyazaki, A. Dirisala, K. Kataoka, H. Cabral, Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor- targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC. Biomaterials 288 121748 (2022) (DOI: 10.1016/j.biomaterials.2022.121748)
  6. T. Miyazaki, S. Chen, S. Florinas, K. Igarashi, Y. Matsumoto, T. Yamasoba, Z.-Q. Xu, H. Wu, C. Gao, K. Kataoka, R. J. Christie, H. Cabral, A hoechst reporter enables visualization of drug engagement in vitro and in vivo: Toward safe and effective nanodrug delivery. ACS Nano 16(8) 12290-12304 (2022) (DOI: 10.1021/acsnano.2c03170)
  7. Y. Tachihara, Y. Nakagawa, T. Miyazaki, Y. Anraku, H. Cabral, Mechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs. Nano Select 3 Issue 8 1242-1251 (2022) (DOI: 10.1002/nano.202100368)
  8. M. Kudo, G. Ishii, N. Gotohda, M. Konishi, S. Takahashi, S. Kobayashi, M. Sugimoto, J. D. Martin, H. Cabral, M. Kojima, Histological tumor necrosis in pancreatic cancer after neoadjuvant therapy. Oncol. Rep. 48(1) 121 (2022) (DOI: 10.3892/or.2022.8332)
  9. W. Yang, P. Chen, E. Boonstra, T. Hong, H. Cabral, Polymeric micelles with pH-responsive cross-linked core enhance in vivo mRNA delivery. Pharmaceutics 14(6) 1205 (2022) (DOI:10.3390/pharmaceutics14061205)
  10. S. Samanta, V. Le Joncour, O. Wegrzyniak, V. K. Rangasami, H. Ali-Loytty, T. Hong, R. K. Selvaraju, O. Aberg, J. Hilborn, P. Laakkonen, O. P. Varghese, O. Eriksson, H. Cabral, O. P. Oommen, Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model. Adv. Therap. 2200001 (2022)
  11. N. Yoshinaga, S. Uchida, A. Dirisala, M. Naito, K. Koji, K. Osada, H. Cabral, K. Kataoka, Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelles for efficient mRNA delivery. Adv. Healthc. Mater. 11(9) 2102016 (2022) (DOI: 10.1002/adhm.202102016)
  12. S. Tanabe, S. Quader, R. Ono, H. Cabral, K. Aoyagi, A. Hirose, H. Yokozaki, H. Sasaki, Molecular network analysis of RNA viral infection pathway in diffuse-and intestinal-type gastric cancer. Fundam. Toxicol. Sci. 9 (2) 37-46 (2022) (DOI: 10.2131/fts.9.37)
  13. S. Tanabe, S. Quader, R. Ono, H. Cabral, K. Aoyagi, A. Hirose, H. Yokozaki, H. Sasaki, The coronavirus-related signaling pathway networks and prediction modeling with activity plots. Proceedings for Annual Meeting of The Japanese Pharmacological Society 3-O-123 (2022) (DOI: 10.1254/jpssuppl.95.0_3-O-123)
  14. Y. Nakagawa, J. Lee, Y. Liu, S. Abbasi, T. Hong, H. Cabral, S. Uchida, M. Ebara, Microglial immunoregulation by apoptotic cellular membrane mimetic polymeric particles. ACS Macro Lett. 11 (2) 270-275 (2022) (DOI: 10.1021/acsmacrolett.1c00643)
  15. T. Yang, Y. Mochida, X. Liu, H. Zhou, J. Xie, Y. Anraku, H. Kinoh, H. Cabral, K. Kataoka, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nat. Biomed. Eng. 5 (11) 1274-1287 (2021) (DOI: 10.1038/s41551-021-00803-z)
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  16. T Zhao, K Asawa, T Masuda, A Honda, K Kushiro, H Cabral, M Takai, Fluorescent polymeric nanoparticle for ratiometric temperature sensing allows real-time monitoring in influenza virus-infected cells. J. Colloid Interface Sci. 601 825-832 (2021) (DOI: 10.1016/j.jcis.2021.05.175)
  17. K. Igarashi, H. Cabral, T. Hong, Y. Anraku, F. Mpekris, T. Stylianopoulos, T. Khan, A. Matsumoto, K. Kataoka, Y. Matsumoto, T. Yamasoba, Vascular bursts act as a versatile tumor vessel permeation route for blood-borne particles and cells. Small 17(42) 2103751 (2021) (DOI: 10.1002/smll.202103751)
  18. W. Yang, T. Miyazaki, P. Chen, T. Hong, M. Naito, Y. Miyahara, A. Matsumoto, K. Kataoka, K. Miyata, H. Cabral, Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro. Sci. Technol. Adv. Mater. 22(1) 850-863 (2021) (DOI: 10.1080/14686996.2021.1976055)
  19. T. Miyazaki, T. Khan, Y. Tachihara, M. Itoh, T. Miyazawa, T. Suganami, Y. Miyahara, H. Cabral, A. Matsumoto, Boronic acid ligands can target multiple subpopulations of pancreatic cancer stem cells via pH-dependent glycan-terminal sialic acid recognition. ACS Appl. Bio Mater. 4(9) 6647-6651 (2021) (DOI:10.1021/acsabm.1c00383)
  20. T. Hong, T. Miyazaki, A. Matsumoto, K. Koji, Y. Miyahara, Y. Anraku, H. Cabral, Phosphorylcholine-installed nanocarriers target pancreatic cancer cells through the phospholipid transfer protein. ACS Biomater. Sci. Eng. 7(9) 4439-4445 (2021) (DOI: 10.1021/acsbiomaterials.1c00730)
  21. J. Liu, H. Cabral, T. Aoki, N. Nishiyama, Y. Huang, K. Kataoka, P. Mi, Nanoprobe-based magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors. ACS Nano 15(8) 13526-13538 (2021) (DOI: 10.1021/acsnano.1c04263)
  22. H. Oda, T. Nagamatsu, H. Cabral, T. Miyazaki, T. Iriyama, K. Kawana, T. Fujii, Y. Osuga, Thrombomodulin promotes placental function by up-regulating placental growth factor via inhibition of high-mobility-group box 1 and hypoxia-inducible factor 1ƒ¿. Placenta 111 1-9 (2021)
  23. E. Boonstra, H. Hatano, Y. Miyahara, S. Uchida, T. Goda, H. Cabral, A proton/macromolecule-sensing approach distinguishes changes in biological membrane permeability during polymer/lipid-based nucleic acid delivery. J. Mater. Chem. B 9 4298-4302 (2021) (DOI: 10.1039/d1tb00645b)
  24. J. Liu, X. Ai, H. Cabral, J. L. Liu, Y. Huang, P. Mi, Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer. Biomaterials 273 120847 (2021) (DOI: 10.1016/j.biomaterials.2021.120847)
  25. N. Yoshinaga, M. Naito, Y. Tachihara, E. Boonstra, K. Osada, H. Cabral, S. Uchida, PEGylation of mRNA by hybridization of complementary PEG-RNA oligonucleotides stabilizes mRNA without using cationic materials. Pharmaceutics 13(6) 800 (2021) (DOI: 10.3390/pharmaceutics13060800)
  26. H. Oda, T. Nagamatsu, D.J. Schust, H. Cabral, T. Miyazaki, T. Iriyama, K. Kawana, Y. Osuga, T. Fujii, Recombinant thrombomodulin attenuates preeclamptic symptoms by inhibiting high mobility group box 1 in mice. Endocrinology 162 Issue4 bqaa248 (2021) (DOI:10.1210/endocr/bqaa248)
  27. H. Shibasaki, H. Kinoh, H. Cabral, S. Quader, Y. Mochida, X. Liu, K. Toh, K. Miyano, Y. Matsumoto, T. Yamasoba, K. Kataoka, Efficacy of pH-sensitive nanomedicines in tumors with different c-MYC expression depends on the intratumoral activation profile. ACS Nano 15 Issue 3 5545-5559 (2021) (DOI: 10.1021/acsnano.1c00364)
  28. N. Yoshinaga, S. Uchida, A. Dirisala, M. Naito, K. Osada, H. Cabral, K. Kataoka, mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency. J. Control. Release 330 317-328 (2021) (DOI: 10.1016/j.jconrel.2020.12.033)
  29. F. Mpekris, M. Panagi, C. Voutouri, J. D. Martin, R. Samuel, S. Takahashi, N. Gotohda, T. Suzuki, P. Papageorgis, P. Demetriou, C. Pierides, L. Koumas, P. Costeas, M. Kojima, G. Ishii, A. Constantinidou, K. Kataoka, H. Cabral, T. Stylianopoulos, Normalizing the microenvironment overcomes vessel compression and resistance to nano-immunotherapy in breast cancer lung metastasis. Adv. Sci. 8 Issue3 2001917 (2021) (DOI: 10.1002/advs.202001917)
  30. Y. Inoue, Y. Matsumoto, K. toh, K. Miyano, H. Cabral, K. Igarashi, S. Iwasaki, K. Kataoka, T. Yamasoba, Manipulating dynamic tumor vessel permeability to enhance polymeric micelle accumulation. J. Control. Release 329 63-75 (2021) (DOI: 10.1016/j.jconrel.2020.11.063)
  31. S. Quader, X. Liu, K. Toh, Y.-L. Su, A. R. Maity, A. Tao, W. K. D. Paraiso, Y. Mochida, H. Kinoh, H. Cabral, K. Kataoka, Supramolecularly enabled pH- triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials 267 120463 (2021) (DOI: 10.1016/j.biomaterials.2020.120463)
  32. N. Nakamura, Y. Mochida, K. Toh, S .Fukushima, Y. Anraku, H Cabral, Effect of mixing ratio of oppositely charged block copolymers on polyion complex micelles for in vivo application. Polymers 13 Issue1 5 (2021) (DOI: 10.3390/polym13010005)
  33. S. Tanabe, S. Quader, R. Ono, H. Cabral, K. Aoyagi, A. Hirose, H. Yokozaki, Molecular network profiling in intestinal-and diffuse-type gastric cancer. Cancers 12 Issue12 3833 (2020) (DOI: 10.3390/cancers12123833)
  34. K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, T. Miyazaki, K. Kataoka, K. Osada, H. Cabral, S. Uchida, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 261 120332 (2020) (DOI: 10.1016/j.biomaterials.2020.120332)
  35. T. Miyazaki, S. Uchida, H. Hatano, Y. Miyahara, A. Matsumoto, H. Cabral, Guanidine-phosphate interactions stabilize polyion complex micelles based on flexible catiomers to improve mRNA delivery. Eur. Polym. 140 110028 (2020) (DOI:10.1016/j.eurpolymj.2020.110028)
  36. H. Kinoh, S. Quader, H. Shibasaki, X. Liu, A. Maity, T. Yamasoba, H. Cabral, K. Kataoka, Translational nanomedicine boosts anti-PD1 therapy to eradicate orthotopic PTEN-negative glioblastoma. ACS Nano 14 Issue 8 10127-10140 (2020) (DOI: 10.1021/acsnano.0c03386)
  37. T. Miyazaki, S. Uchida, S. Nagatoishi, K. Koji, T. Hong, S. Fukushima, K. Tsumoto, K. Ishihara, K. Kataoka, H. Cabral, Polymeric nanocarriers with controlled chain flexibility boost mRNA delivery in vivo through enhanced structural fastening. Adv. Healthc. Mater. 9 Issue 16 2000538 (2020) (DOI: 10.1002/adhm.202000538)
  38. T. Khan, K. Igarashi, A. Tanabe, T. Miyazawa, S. Fukushima, Y. Miura, Y. Matsumoto, T. Yamasoba, A. Matsumoto, H. Cabral, K. Kataoka, Structural control of boronic acid ligands enhances intratumoral targeting of sialic acid to eradicate cancer stem-like cells. ACS. Applied. Bio Mater. 3 Issue 8 5030-5039 (2020) (DOI: 10.1021/acsabm.0c00530)
  39. M. Kudo, T. Kobayashi, N. Gotohda, M. Konishi, S. Takahashi, S. Kobayashi, M. Sugimoto, S. Okubo, J. D. Martin, H. Cabral, G. Ishii, M. Kojima, Clinical utility of histological and radiological evaluations of tumor necrosis for predicting prognosis in pancreatic cancer. Pancreas 49 Issue5 634-641 (2020) (DOI: 10.1097/MPA.0000000000001539)
  40. H. Kinoh, H. Shibasaki, X. Liu, T. Yamasoba, H. Cabral, K. Kataoka, Nanomedicines blocking adaptive signals in cancer cells overcome tumor TKI resistance. J. Control. Release 321 132-144 (2020) (DOI: 10.1016/j.jconrel.2020.02.008)
  41. S. Uchida, K. Yanagihara, A. Matsui, K. Kataoka, K. Itaka, mRNA as a tool for gene transfection in 3D cell culture for future regenerative therapy. micromachines 11 Issue4 426 (2020) (DOI: 10.3390/mi11040426)
  42. R. Ueki, S. Uchida, N. Kanda, N. Yamada, A. Ueki, M. Akiyama, K. Toh, H. Cabral, S. Sando, A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application. Sci. Adv. 6 14 eaay2801 (2020) (DOI: 10.1126/sciadv.aay2801)
  43. C. Qin, X. Hou, T. Khan, N. Nitta, M. Yanagawa, Y. Sakurai, M. Suzuki, S. Masunaga, H. Tanaka, Y. Sakurai, H. Takahashi, I. Aoki, H. Yanagie, H. Cabral, Enhanced MRI‐guided gadolinium (III) neutron capture therapy by polymeric nanocarriers promoting tumor accumulation and intracellular delivery. ChemNanoMat 6 Issue 3 412-419 (2020) (DOI: 10.1002/cnma.201900730)
  44. A. Tao, G. L. Huang, K. Igarashi, T. Hong, S. Liao, F. Stellacci, Y. Matsumoto, T. Yamasoba, K. Kataoka, H. Cabral, Polymeric micelles loading proteins through concurrent ion complexation and pH-cleavable covalent bonding for in vivo delivery. Macromol. Biosci. 20 Issue1 1900161 (2020) (DOI: 10.1002/mabi.201900161)
  45. M. Panagi, C. Voutouri, F. Mpekris, P. Papageorgis, M. R. Martin, J. D. Martin, P. Demetriou, C. Pierides, C. Polydorou, A. Stylianou, M. Louca, L. Koumas, P. Costeas, K. Kataoka, H. Cabral, T. Stylianopoulos, TGF-ƒÀ inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity. Theranostics 10 (4) 1910-1922 (2020) (DOI: 10.7150/thno.36936)
  46. T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka, Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer. ACS Nano 13 Issue11 12732-12742 (2019) (DOI: 10.1021/acsnano.9b04676)
  47. T. Miyazaki, K. Igarashi, Y. Matsumoto, H. Cabral, One-pot synthesis of PEG-poly (amino acid) block copolymers assembling polymeric micelles with PEG-detachable functionality. ACS Biomater. Sci. Eng. 5 Issue11 5727-5733 (2019) (DOI: 10.1021/acsbiomaterials.8b01549)
  48. Y. Nakagawa, Y. Yano, J. Lee, Y. Anraku, M. Nakakido, K. Tsumoto, H. Cabral, M. Ebara, Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Diseases Treatment. ACS Biomater. Sci. Eng. 5 Issue11 5705-5713 (2019) (DOI: 10.1021/acsbiomaterials.8b01510)
  49. N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida, Bundling mRNA strands to prepare nano-assemblies with enhanced stability towards RNase for in vivo delivery. Angew. Chem. Int. Ed. 58 Issue33 11360-11363 (2019) (DOI: 10.1002/anie.201905203)
  50. J. Martin, M. Panagi, C. Wang, T. Khan, M. Martin, C. Voutouri, K. Toh, P. Papageorgis, F. Mpekris, C. Polydorou, G. Ishii, S. Takahashi, N. Gotohda, T. Suzuki, M. Wilhelm, V. Melo, S. Quader, J. Norimatsu, R. Lanning, M. Kojima, M. Stuber, T. Stylianopoulos, K. Kataoka, H. Cabral, Dexamethasone increases cisplatin-loaded nanocarrier delivery and efficacy in metastatic breast cancer by normalizing the tumor microenvironment. ACS Nano 13 Issue6 6396-6408 (2019) (DOI: 10.1021/acsnano.8b07865)
  51. A. Dirisala, S. Uchida, T. A. Tockary, N. Yoshinaga, J. Li, S. Osawa, L. Gorantla, S. Fukushima, K. Osada, K. Kataoka, Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability. J. Drug Target. 27 Issue5-6 670-680 (2019) (DOI: 10.1080/1061186X.2018.1550646)
  52. K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saka, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 301 10 28-41 (2019) (DOI: 10.1016/j.jconrel.2019.02.021)
  53. G. L. Huang, A. Tao, T. Miyazaki, T. Khan, T. Hong, Y. Nakagawa, H. Cabral, PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials 9 (5) 719 (2019) (DOI: 10.3390/nano9050719)
  54. S. Watanabe, K. Hayashi, K. Toh, H. J. Kim, X. Liu, H. Chaya, S. Fukushima, K. Katsushima, Y. Kondo, S. Uchida, S. Ogura, T. Nomoto, H. Takemoto, H. Cabral, H. Kinoh, H. Tanaka, M. R. Kano, Y. Matsumoto, H. Fukuhara, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer. Nat. Commun. 10 1894 (2019) (DOI: 10.1038/s41467-019-09856-w)
  55. S. Kurimoto, N. Yoshinaga, K. Igarashi, Y. Matsumoto, H. Cabral, S. Uchida, PEG-oligoRNA hybridization of mRNA for developing sterically stable lipid nanoparticles toward in vivo administration. Molecules 24 (7) 1303 (2019) (DOI: 10.3390/molecules24071303)
  56. N. Yoshinaga, S. Uchida, M. Naito, K. Osada, H. Cabral, K. Kataoka, Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection. Biomaterials 197 255-267 (2019) (DOI: 10.1016/j.biomaterials.2019.01.023)
  57. Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 295 268-277 (2019) (DOI: 10.1016/j.jconrel.2019.01.006)
  58. T. Chida, Y. Miura, H. Cabral, T. Nomoto, K. Kataoka, N. Nishiyama, Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release. J. Control. Release 292 130-140 (2018) (DOI: 10.1016/j.jconrel.2018.10.035)
  59. M. Hori, H. Cabral, K. Toh, A. Kishimura, K. Kataoka, Robust polyion complex vesicles (PICsomes) under physiological condition reinforced by multiple hydrogen bond formation derived by guanidinium groups. Biomacromolecules 19 4113-4121(2018) (DOI: 10.1021/acs.biomac.8b01097)
  60. M. Suhara, Y. Miura, H. Cabral, D. Akagi, Y. Anraku, A. Kishimura, M. Sano, T. Miyazaki, N. Nakamura, A. Nishiyama, K. Kataoka, H. Koyama, K. Hoshina, Targeting ability of self-assembled nanomedicines in rat acute limb ischemia model is affected by size. J. Control. Release 286 394-401 (2018) (DOI: 10.1016/j.jconrel.2018.07.049)
  61. H. Cabral, K. Miyata, K. Osada, K. kataoka, Block copolymer micelles in nanomedicine applications.Chem. Rev. 118 14 6844-6892 (2018) (DOI: 10.1021/acs.chemrev.8b00199)
  62. N. Yoshinaga, T. Ishii, M. Naito, T. Endo, S. Uchida, H. Cabral, K. Osada, K. Kataoka, Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration. J. Am. Chem. Soc. 139 (51) 18567-18575 (2017) (DOI: 10.1021/jacs.7b08816)
  63. J. Zhang, H. Kinoh, L. Hespel, X. Liu, S. Quader, J. Martin, T. Chida, H. Cabral, K. Kataoka, Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles. J. Control. Release 264 127-135 (2017) (DOI: 10.1016/j.jconrel.2017.08.025)
  64. S. Chen, S. Florinas, A. Teitgen, Z.-Q. Xu, C. Gao, H. Wu, K. Kataoka, H. Cabral, R. J. Christie Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity. Sci. Technol. Adv. Mater. 18 (1) 666-680 (2017) (DOI: 10.1080/14686996.2017.1370361)
  65. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 261 275-286 (2017) (DOI: 10.1016/j.jconrel.2017.06.021)
  66. A. Matsumoto, A. J. S.-Brown, T. Khan, T. Miyazawa, H. Cabral, K. Kataoka, Y. Miyahara, Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment. Chem. Sci. 8 (9) 6165-6170 (2017) (DOI: 10.1039/C7SC01905J)
  67. H. Wu, A. Tao, J. D. Martin, S. Quader, X. Liu, K. Takahashi, L. Hespel, Y. Miura, Y. Hayakawa, T. Irimura, H. Cabral, K. Kataoka, Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-ƒÈB inhibition. J. Pharm. Sci. 106 (9) 2438-2446 (2017) (DOI: 10.1016/j.xphs.2017.03.031)
  68. K. Klinker, O. Schafer, D. Huesmann, T. Bauer, L. Capeloa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, M. Barz, Secondary structure-driven self-assembly of reactive polypept(o)ides: Controlling size, shape and function of core cross-linked nanostructures. Angew. Chem. Int. Ed. 56 (32) 9608-9613 (2017) (DOI: 10.1002/anie.201702624)
  69. S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka, cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J. Control. Release 258 56-66 (2017) (DOI: 10.1016/j.jconrel.2017.04.033)
  70. P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka, Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors. J. Control. Release 254 1-9 (2017) (DOI: 10.1016/j.jconrel.2017.03.036)
  71. P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka, A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy. Nat. Nanotechnol. 11 (8) 724-730 (2016) (DOI: 10.1038/nnano.2016.72)
  72. R. N. Gilbreth, S. Novarra, L. Wetzel, S. Florinas, H. Cabral, K. Kataoka, J. RiosDoria, R. J. Christie, M. Baca, Lipid- and polyion complex-based micelles as agonist platforms for TNFR superfamily receptors. J. Control. Release 234 104-114 (2016) (DOI: 10.1016/j.jconrel.2016.05.041)
  73. H. Kinoh, Y. Miura, T. Chida, X. Liu, K. Mizuno, S. Fukushima, Y. Morodomi, N. Nishiyama, H. Cabral, K. Kataoka, Nanomedicines eradicating cancer stem-like cells in vivo by pH-triggered intracellular cooperative action of loaded drugs. ACS Nano 10 (6) 5643-5655 (2016) (DOI: 10.1021/acsnano.6b00900)

    ▶ See also: ACS EditorsfChoice (June 2016)
  74. Y. Matsumoto, Y. Miyamoto, H. Cabral, Y. Matsumoto, K. Nagasaka, S. Nakagawa, D. Maeda, T. Yano, K. Oda, K. Kawana, N. Nishiyama, K. Kataoka, T. Fujii, Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132. Cancer Sci. 107 (6) 773-781 (2016) (DOI: 10.1111/cas.12926)
  75. Y. Matsumoto, J. W. Nichols, K. Toh, T. Nomoto, H. Cabral, Y. Miura, R. J. Christie, N. Yamada, T. Ogura, M. R. Kano, Y. Matsumura, N. Nishiyama, T. Yamasoba, Y. -H. Bae, K. Kataoka, Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nat. Nanotechnol. 11 (6) 533-538 (2016) (DOI: 10.1038/nnano.2015.342)
    ▶ See also: F.-R. E. Curry, Drug delivery: Redefining tumour vascular barriers 11 (6) 494-496 (2016) (DOI: 10.1038/nnano.2016.21)
  76. F. Perche, Y. Yi, L. Hespel, P. Mi, A. Dirisala, H. Cabral, K. Miyata, K. Kataoka, Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials 90 62-71 (2016) (DOI: 10.1016/j.biomaterials.2016.02.027)
  77. S. Sakai, C. Iwata, H.Y. Tanaka, H. Cabral, Y. Morishita, K. Miyazono, M.R. Kano, Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2. J. Control. Release 230 109-115 (2016) (DOI: 10.1016/j.jconrel.2016.04.007)
  78. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 230 26-33 (2016) (DOI: 10.1016/j.jconrel.2016.03.038)
  79. S. Florinas, M. Liu, R. Fleming, L. V. V.-Ysla, J. Ayriss, R. Gilbreth, N. Dimasi, C. Gao, H. Wu, Z.-Q. Xu, S. Chen, A. Dirisala, K. Kataoka, H. Cabral, R. J. Christie, A Nanoparticle platform to evaluate bioconjugation and receptor-mediated cell uptake using crosslinked polyion complex micelles bearing antibody fragments. Biomacromolecules 17 (5) 1818-1833 (2016) (DOI: 10.1021/acs.biomac.6b00239)
  80. N. Dewi, P. Mi, H. Yanagie, Y. Sakurai, Y. Morishita, M. Yanagawa, T. Nakagawa, A. Shinohara, T. Matsukawa, K. Yokoyama, H. Cabral, M. Suzuki, Y. Sakurai, H. Tanaka, K. Ono, N. Nishiyama, K. Kataoka, H. Takahashi, In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent. J. Cancer Res. Clin. Oncol. 142 (4) 767-775 (2016) (DOI: 10.1007/s00432-015-2085-0)
  81. A. Kim, Y. Miura, T. Ishii, O. F. Mutaf, N. Nishiyama, H. Cabral, K. Kataoka, Intracellular delivery of charge-converted monoclonal antibodies by combinatorial design of block/homo polyion complex micelles. Biomacromolecules 17 (2) 446-453 (2016) (DOI: 10.1021/acs.biomac.5b01335)
  82. J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, M. Wang, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 220 PartB 783-791 (2015) (DOI: 10.1016/j.jconrel.2015.10.017)
  83. Y. Miura, A. B. Tsuji, A. Sugyo, H. Sudo, I. Aoki, M. Inubushi, M. Yashiro, K. Hirakawa, H. Cabral, N. Nishiyama, T. Saga, K. Kataoka, Polymeric micelle platform for multimodal tomographic imaging to detect scirrhous gastric cancer. ACS Biomater. Sci. Eng. 1 (11) 1067-1076 (2015) (DOI: 10.1021/acsbiomaterials.5b00142)
  84. N. Q. Vinh, S. Naka, H. Cabral, H. Murayama, S. Kaida, K. Kataoka, S. Morikawa, T. Tani, MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model. Int. J. Nanomedicine 10 4137-4147 (2015) (DOI: 10.2147/IJN.S81339)
  85. P. Mi, N. Dewi, H. Yanagie, D. Kokuryo, M. Suzuki, Y. Sakurai, Y. Li, I. Aoki, K. Ono, H. Takahashi, H. Cabral, N. Nishiyama, K. Kataoka, Hybrid calcium phosphate-polymeric micelles incorporating gadolinium chelates for imaging-guided gadolinium neutron capture tumor therapy. ACS Nano 9 (6) 5913-5921 (2015) (DOI: 10.1021/acsnano.5b00532)
  86. H. Cabral, J. Makino, Y. Matsumoto, P. Mi, H. Wu, T. Nomoto, K. Toh, N. Yamada, Y. Higuchi, S. Konishi, M. R. Kano, H. Nishihara, Y. Miura, N. Nishiyama, K. Kataoka, Systemic targeting of lymph node metastasis through the blood vascular system by using size-controlled nanocarriers. ACS Nano 9 (5) 4957-4967 (2015) (DOI: 10.1021/nn5070259)
  87. J. -Y. Ahn, Y. Miura, N. Yamada, T. Chida, X. Liu, A. Kim, R. Sato, R. Tsumura, Y. Koga, M. Yasunaga, N. Nishiyama, Y. Matsumura, H. Cabral, K. Kataoka, Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer. Biomaterials 39 23-30 (2015) (DOI: 10.1016/j.biomaterials.2014.10.069)
  88. H.-C. Yen, H. Cabral, P. Mi, K. Toh, Y. Matsumoto, X. Liu, H. Koori, A. Kim, K. Miyazaki, Y. Miura, N. Nishiyama, K. Kataoka, Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy. ACS Nano 8 (11) 11591-11602 (2014) (DOI: 10.1021/nn504836s)
  89. H. Wu, H. Cabral, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka, Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation. J. Control. Release 189 1-10 (2014) (DOI: 10.1016/j.jconrel.2014.06.018)
  90. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to effcient antitumor therapy. J. Control. Release 188 67-77 (2014) (DOI: 10.1016/j.jconrel.2014.05.048)
  91. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor. ACS Nano 8 (7) 6724-6738 (2014) (DOI: 10.1021/nn500498t)
  92. H. -J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014) (DOI: 10.1016/j.biomaterials.2014.02.016)
  93. F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. Takemoto, H. -J. Kim, N. Nishiyama, K. Miyata, K. Kataoka, Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J. Control. Release 178 18-24 (2014) (DOI: 10.1016/j.jconrel.2014.01.008)
  94. C. V. Synatschke, T. Nomoto, H. Cabral, M. Fortsch, K. Toh, Y. Matsumoto, K. Miyazaki, A. Hanisch, F. H. Schacher, A. Kishimura, N. Nishiyama, A. H. E. Mueller, K. Kataoka, Multicompartment micelles with adjustable poly(ethylene glycol) shell for efficient in vivo photodynamic therapy. ACS Nano 8 (2) 1161-1172 (2014) (DOI: 10.1021/nn4028294)
  95. P. Mi, D. Kokuryo, H. Cabral, M. Kumagai, T. Nomoto, I. Aoki, Y. Terada, A. Kishimura, N. Nishiyama, K. Kataoka, Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors. J. Control. Release 174 63-71 (2014) (DOI: 10.1016/j.jconrel.2013.10.038)
  96. H. Chen, L. Xiao, Y. Anraku, P. Mi, X. Liu, H. Cabral, A. Inoue, T. Nomoto, A. Kishimura, N. Nishiyama, K. Kataoka, Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J. Am. Chem. Soc. 136 (1) 157-163 (2014) (DOI: 10.1021/ja406992w)
  97. Y. Miura, T. Takenaka, K. Toh, S. Wu, H. Nishihara, M. R. Kano, Y. Ino, T. Nomoto, Y. Matsumoto, H. Koyama, H. Cabral, N. Nishiyama, K. Kataoka, Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier. ACS Nano 7 (10) 8583-8592 (2013) (DOI: 10.1021/nn402662d)
  98. S. Deshayes, H. Cabral, T. Ishii, Y. Miura, S. Kobayashi, T. Yamashita, A. Matsumoto, Y. Miyahara, N. Nishiyama, K. Kataoka, Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors. J. Am. Chem. Soc. 135 (41) 15501-15507 (2013) (DOI: 10.1021/ja406406h)
  99. H. Cabral, M. Murakami, H. Hojo, Y. Terada, M. R. Kano, U. -I. Chung, N. Nishiyama, K. Kataoka, Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc. Natl. Acad. Sci. USA. 110 (28) 11397-11402 (2013) (DOI: 10.1073/pnas.1301348110) (PDF File)
  100. P. Mi, H. Cabral, D. Kokuryo, M. Rafi, Y. Terada, I. Aoki, T. Saga, T. Ishii, N. Nishiyama, K. Kataoka, Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging. Biomaterials 34 (2) 492-500 (2013) (DOI: 10.1016/j.biomaterials.2012.09.030)
  101. K. Osada, H. Cabral, Y. Mochida, S. -E. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation. J. Am. Chem. Soc. 134 (32) 13172-13175 (2012) (DOI: 10.1021/ja304615y)
  102. M. Rafi, H. Cabral, M. R. Kano, P. Mi, C. Iwata, M. Yashiro, K. Hirakawa, K. Miyazono, N. Nishiyama, K. Kataoka, Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis. J. Control. Release 159 (2) 189-196 (2012) (DOI: 10.1016/j.jconrel.2012.01.038)
  103. H. Hosoya, K. Kadowaki, M. Matsusaki, H. Cabral, H. Nishihara, H. Ijichi, K. Koike, K. Kataoka, K. Miyazono, M. Akashi, M. R. Kano, Engineering fibrotic tissue in pancreatic cancer: A novel three-dimensional model to investigate nanoparticle delivery. Biochem. Biophys. Res. Commun. 419 (1) 32-37 (2012) (DOI: 10.1016/j.bbrc.2012.01.117)
  104. M. Baba, Y. Matsumoto, A. Kashio, H. Cabral, N. Nishiyama, K. Kataoka, T. Yamasoba, Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs. J. Control. Release 157 (1) 112-117 (2012) (DOI: 10.1016/j.jconrel.2011.07.026)
  105. H. -J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka, PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor. J. Drug Target. 20 (1) 33-42 (2012) (DOI: 10.3109/1061186X.2011.632010)
  106. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 6 (12) 815-823 (2011) (DOI: 10.1038/nnano.2011.166)
  107. M. Murakami, H. Cabral, Y. Matsumoto, S. Wu, M. R. Kano, T. Yamori, N. Nishiyama, K. Kataoka, Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Sci. Transl. Med. 3 (64) 64ra2 (2011) (DOI: 10.1126/scitranslmed.3001385)
  108. Y. Matsumoto, T. Nomoto, H. Cabral, Y. Matsumoto, S. Watanabe, R. J. Christie, K. Miyata, M. Oba, T. Ogura, Y. Yamasaki, N. Nishiyama, T. Yamasoba, K. Kataoka, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Express 1 (4) 1209-1216 (2010) (DOI: 10.1364/BOE. 1.001209)
  109. S. Kaida, H. Cabral, M. Kumagai, A. Kishimura, Y. Terada, M. Sekino, I. Aoki, N. Nishiyama, T. Tani, K. Kataoka, Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. Cancer Res. 70 (18) 7031-7041 (2010) (DOI: 10.1158/0008-5472.CAN-10-0303)
  110. M. Kumagai, T. K. Sarma, H. Cabral, S. Kaida, M. Sekino, N. Herlambang, K. Osada, M. R. Kano, N. Nishiyama, K. Kataoka, Enhanced in vivo magnetic resonance imaging of tumors by PEGylated iron-oxide-gold core-shell nanoparticles with prolonged blood circulation properties. Macromol. Rapid Commun. 31 (17) 1521-1528 (2010) (DOI: 10.1002/marc.201000341)
  111. A. Matsumoto, H. Cabral, N. Sato, K. Kataoka, Y. Miyahara, Assessment of tumor metastasis by the direct determination of cell-membrane sialic acid expression. Angew. Chem. Int. Ed. 49 (32) 5494-5497 (2010) (DOI: 10.1002/anie.201001220)
  112. Y. Lee, T. Ishii, H. Cabral, H. -J. Kim, J. -H. Seo, N. Nishiyama, H. Oshima, K. Osada, K. Kataoka, Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. Angew. Chem. Int. Ed. 48 (29) 5309-5312 (2009) (DOI: 10.1002/anie.200900064)
  113. H. Cabral, M. Nakanishi, M. Kumagai, W. -D. Jang, N. Nishiyama, K. Kataoka, A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles. Pharm. Res. 26 (1) 82-92 (2009) (DOI: 10.1007/s11095-008-9712-2)
  114. H. Cabral, N. Nishiyama, K. Kataoka, Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity. J. Control. Release 121 (3) 146-155 (2007) (DOI: 10.1016/ j.jconrel. 2007.05.024)
  115. H. Cabral, N. Nishiyama, S. Okazaki, H. Koyama, K. Kataoka, Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. J. Control. Release 101 (1-3) 223-232 (2005) (DOI: 10.1016/j.jconrel.2004.08.022)
  116. H. Cabral, M. Cisneros, J.M. Kenny, A. Vazquez, C. Bernal, Structure-properties relationship of short jute fiber-reinforced polypropylene composites. J. Compos. Mater. 39 51-65 (2005) (DOI: 10.1177/0021998305046434)
  117. N. Nishiyama, S. Okazaki, H. Cabral, M. Miyamoto, Y. Kato, Y. Sugiyama, K. Nishio, Y. Matsumura, K. Kataoka, Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res. 63 (24) 8977-8983 (2003)