Latest News
Glycoliposomes target lymphatic dendritic cells in a size-dependent manner to activate natural killer T cells against breast tumors
Taehun Hong, Keita Masuda, Yuki Nakashima, Shangwei Li, Pengwen Chen, Guanghao Hu, Kazunori Igarashi, Ayumi Kimura, Koji Fujita, Tomohiro Umezu, Masahiko Kuroda, Horacio Cabral JCR. 2025 Abstract Glycolipids have high potential for activating natural killer T (NKT) cells to mediate robust antitumor responses. However, critical challenges, such as low baseline NKT cell counts and the risk of unintentionally engaging immunosuppressive NKT subsets that dampen immune activation, have limited their clinical efficacy. Because antitumor NKT cells are functionalized by…
Early Career Editorial Board Member
We are honoured to announce that Dr. Pengwen Chen has been selected to serve on the Early Career Editorial Board of Pharmaceutics. Congratulations!
Best Presentation Award
Dr. Chen Pengwen was awarded the Best Presentation Award in The 41st Annual Meeting of the Japan Society of Drug Delivery System. Congratulations!
Top-viewed paper in Advacned Science!
Our lab’s paper, ‘An IL-12-based nano cytokine safely potentiates anticancer immunity through spatiotemporal control of inflammation to eradicate advanced cold tumors,’ was awarded the top-viewed paper in Advanced Science!
Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner
John D. Martin, Kazuko Toh, Margaret R. Martin, Pengwen Chen, Chenyu Wang, Kazunori Igarashi, Fotios Mpekris, Triantafyllos Stylianopoulos, Matthew D. Stuber, Kazunori Kataoka, Horacio Cabral JCR. 2025 Abstract Bone marrow (BM) has roles in health and disease, so systemically administered nanocarriers (NCs) targeting or avoiding BM are desirable. While the hydrodynamic diameter of NCs can be tuned to target or avoid various organs, the size dependence of extravasation from BM vessels is unknown. To clarify the…
